Product introduction
p-Toluenesulfonyl chloride (Tosyl chloride, TsCl) is a widely used sulfonyl chloride reagent (para-toluenesulfonyl chloride) supplied commercially in reagent and technical grades. It is employed primarily to convert hydroxyl and amine functionalities into activated tosyl derivatives (tosylates and sulfonamides), enabling downstream substitutions, eliminations and protective-group strategies in multi-step synthesis. Material is supplied as a white to off-white crystalline solid; request lot Certificate of Analysis (CoA) and Safety Data Sheet (SDS) to confirm assay and moisture specification before qualification.
Applications & Descriptions
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Tosylation (Alcohol Activation)
Converts alcohols to tosylates (ROTs), creating excellent leaving groups for subsequent substitution or elimination chemistry. -
Sulfonamide Formation (Amine Protection / Functionalisation)
Reacts with amines to form sulfonamides (R–SO₂–NR₂), used in protective-group strategies and for introducing sulfonyl functionality. -
Dehydration & Leaving-Group Transformation
Facilitates dehydrations, halide formation and other transformations where activation of OH or conversion to a better leaving group is required. -
Intermediate For Heterocycle & Specialty Synthesis
Used as an electrophilic sulfonyl donor in the preparation of heterocycles, sulfonylated intermediates and specialty reagents. -
Laboratory Reagent & Process Chemistry
Standard reagent for bench and pilot synthetic chemistry: preparative tosylations, derivatisation, and method development.
