Tetrahydropyran

Product Introduction

Tetrahydropyran (CAS 142-68-7), also known as THP or Oxane, is a saturated six-membered cyclic ether with the chemical formula C5H10O. It is a colorless, volatile liquid with an ethereal odor similar to Tetrahydrofuran (THF). Tetrahydropyran (CAS 142-68-7) is widely used in organic chemistry both as a specialty solvent and as a critical reagent for the protection of hydroxyl groups. Its unique ring size and stability make it an excellent choice for complex chemical transformations where traditional ethers might be too volatile or reactive.

Product Selling Points

• Superior Protecting Agent: The industry standard for the formation of THP ethers, protecting alcohols and phenols during multi-step synthesis.

• Excellent Solvent Stability: Offers high resistance to strong bases and organometallic reagents, often outperforming THF in specific high-temperature reactions.

• High Purity (≥ 99.5%): Chemfine ensures extremely low moisture and peroxide content, critical for sensitive catalytic processes.

• Controlled Peroxide Levels: Formulated with high-grade stabilizers to ensure safety during long-term storage and distillation.

• Ideal Boiling Point: Its boiling point (88°C) allows for easier recovery and separation compared to lower-boiling ethers.

• Broad Compatibility: Miscible with water and almost all common organic solvents, including alcohols, esters, and hydrocarbons.

Applications

Alcohol and Phenol Protection Used as a primary reagent to form Tetrahydropyranyl (THP) ethers, protecting sensitive hydroxyl groups during complex organic synthesis.

Specialty Reaction Solvent Functions as an effective solvent for Grignard reagents and lithiation reactions, particularly where higher reaction temperatures are required than THF allows.

Pharmaceutical Intermediate Synthesis Acts as a building block in the production of various active pharmaceutical ingredients (APIs), especially those involving pyranose ring structures.

Agrochemical Manufacturing Utilized as a solvent and intermediate in the synthesis of modern herbicides and fungicides to improve yield and selectivity.

Resin and Coating Formulations Serves as a specialty solvent in high-performance resin systems to improve flow characteristics and solubility of polymer components.

Packaging

Standard industrial packaging options for Tetrahydropyran include:

• 180kg tight-head steel drums (Standard export packaging).

• 900kg IBC tanks for high-volume industrial production.

• ISO Tanks for large-scale international bulk shipments.

• All packaging is nitrogen-blanketed to minimize peroxide formation and maintain anhydrous quality.

Storage

Tetrahydropyran is a highly flammable liquid and can form explosive peroxides. It must be stored in a cool, dry, and well-ventilated warehouse away from heat, sparks, and open flames. Store in a dedicated flammable liquids area with secondary containment. Keep containers tightly sealed and protect from light. Store away from strong oxidizing agents and acids. Regularly test for peroxide levels if stored for extended periods. Properly stored, it has a shelf life of 12 months.

Related and Similar Products

1. Tetrahydrofuran (THF) – CAS 109-99-9

2. 1,4-Dioxane – CAS 123-91-1

3. 2-Methyltetrahydrofuran – CAS 96-47-9

4. Dihydropyran (DHP) – CAS 110-87-2

5. Cyclopentyl Methyl Ether (CPME) – CAS 5614-37-9

6. Isopropyl Ether – CAS 108-20-3

7. Methyl Tert-Butyl Ether (MTBE) – CAS 1634-04-4

8. Ethyl Ether – CAS 60-29-7

9. Pyran – CAS 289-66-7

10. Tetrahydrofurfuryl Alcohol – CAS 97-99-4